Sol-Gel Announces Initiation of SGT-210 Phase 1 Proof of Concept Study in Palmoplantar Keratoderma (PPK)
“Patients with PPK suffer from the physical manifestations of the disease and the thickened skin can interfere with daily activities,” said Dr.
The Phase 1 proof of concept study SGT-84-01 is a single-center, single-blinded, vehicle-controlled study designed to evaluate the bioavailability, safety and tolerability of SGT-210 as well as inform on potential efficacy. The study is targeting enrollment of approximately 15 patients to undergo a three month treatment period, followed by a three month follow-up period.
“Initiation of this study is another important step forward with our SGT-210 development program into PPK and to expand our proprietary pipeline,” commented Dr.
About Palmoplantar Keratoderma
Palmoplantar keratoderma (PPK) is a group of skin conditions characterized by the thickening of the skin on the palms and soles of the feet. PPK may lead to impairment of quality of life through pain, decreased acral functionality and cosmetic concerns. Traditional therapeutic approaches for PPK are mainly based on decreasing scale, controlling hyperkeratosis and blunting inflammation when present. Existing remedies may further impair the epidermal barrier and lead to compensatory exaggerated epidermal proliferation. Therefore, safe and effective management of PPK represents an important unmet medical need.
SGT-210 is a topically administered, epidermal growth factor receptor (EGFR) inhibitor. EGFR is a growth factor receptor that induces cell differentiation and proliferation upon activation through the binding of one of its ligands. It is believed that SGT-210 will work to inhibit this action and thus address the excessive skin growth and thickening which results in the significant impairment associated with PPK disorders. Prevalence estimates of PPK suggest approximately 90,000 people in the US alone may have some variant of the disease. Should SGT-210 succeed, it may represent a US market potential of approximately
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|Sol-Gel Contact:||U.S. Investor Contact:||Media Contact:|
|Gilad Mamlok||Chiara Russo||Stephanie Bukantz|
|Chief Financial Officer||Solebury Trout||Chamberlain Healthcare PR|
Source: Sol-Gel Technologies Ltd.